Sermorelin nasal spray
Sermorelin nasal spray: does it work, and what does it cost?
Sermorelin sprayed into the nose can raise growth hormone, but very little of it gets through. The one human study that measured absorption, in 30 healthy men, put nasal bioavailability at 3% to 5% and needed about 50 times the intravenous dose for a similar growth hormone response. In a six-month trial of an intranasal formulation in eight children, the response faded, three children developed antibodies and height velocity did not rise. None of these studies tested the compounded nasal sprays sold online, and compounded drugs are not FDA-approved. Three sellers publish prices: BMI MD at $129 for a one-month plan, AgelessRx at $149 for the first month and $199 after, and LaSara at $199 for a one-month subscription. Only LaSara publishes a concentration and bottle size.
Sets the human intranasal studies, with the absorption and dose figures they reported, beside what three sellers publish about their sprays today. It is a bounded source review, not a systematic review or individual medical advice.
Nasal absorption
3% to 5% in the one study that measured it
Evidence for today's sprays
None of the cited studies tested a compounded product sold online
Published first-month prices
$129 to $199; one seller of three states strength and bottle size
Swipe the evidence table sideways to read every column.
| Study | Who was studied | What was given | What it found |
|---|---|---|---|
| Wilton and colleagues, 1993 | 30 healthy men aged 19 to 43 | Sermorelin by vein or through the nose | Nasal bioavailability of 3% to 5%. The largest nasal response came at about 50 micrograms per kg, roughly as potent as 1 microgram per kg by vein |
| Hümmelink and colleagues, 1993 | Eight short prepubertal children | Sermorelin through the nose, 50 micrograms per kg three times a day for six months | Growth hormone peaks shrank by six weeks and again by six months. Three children developed antibodies. Six-month height velocity did not rise |
| Borkenstein, 1986 | Five prepubertal children with short stature | One nasal dose of sermorelin, 100 micrograms per kg | Growth hormone peaked at 15 minutes and was still raised at two hours. One child reported nasal burning |
| Vance and colleagues, 1986 | Healthy men | A closely related analogue by vein, under the skin and through the nose | A nasal dose thirty times the intravenous dose released about one fifth as much growth hormone |
| Perras and colleagues, 1999 | 12 young and 11 older healthy men | One 300 microgram nasal dose of growth hormone-releasing hormone before bed | A smaller growth hormone rise in early sleep, with more REM and slow-wave sleep later in the night |
Which sermorelin nasal spray offers are publicly priced?
Providers are listed alphabetically. These are public headlines, not equivalent prescriptions or complete quotes. Product quantity, concentration and billing terms must match before a price can be compared.
| Provider | Published format | Advertised price | Still missing |
|---|---|---|---|
 AgelessRx sermorelin Source checked October 11, 2026 | Compounded sermorelin nasal spray | $149 first month; $199 per month after | Concentration, bottle size, sprays per bottle, dispensing pharmacy and required fees |
 BMI MD sermorelin Source checked October 11, 2026 | Sermorelin nasal spray | $129 one-month plan; $119/month equivalent with a $357 three-month total; $109/month equivalent with a $654 six-month total | Concentration, bottle size, amount charged at checkout, renewal and required fees |
| LaSara Medical Group sermorelin Source checked October 11, 2026 | Sermorelin nasal spray, 4 mL bottle at 200 micrograms per 0.1 mL | $199 one-month subscription; $249 one-month plan | Dispensing pharmacy, renewal terms, required fees and which use instructions apply |
BMI MD's partner offer requires a location check and excludes California and South Carolina; a direct provider option remains available. AgelessRx and LaSara use direct official links. We may earn a commission from qualifying partner referrals. Link type does not change the table or evidence conclusion.
Does sermorelin nasal spray actually work?
It can raise growth hormone, but only a small share of the dose is absorbed. In 30 healthy men aged 19 to 43, sermorelin given through the nose released growth hormone in a dose-dependent way. The largest response came at about 50 micrograms per kg of body weight, which was roughly as potent as 1 microgram per kg given by vein. The study put nasal bioavailability at 3% to 5%.
A hormone response in a research setting is not a treatment result. In the one longer trial, eight children used an intranasal formulation three times a day for six months. Their growth hormone peaks shrank over time and their height velocity did not rise. None of these studies tested a compounded spray sold online, and none measured muscle or body fat.
Is sermorelin nasal spray as effective as injections?
No study here compares a nasal spray with the under-the-skin injections sold online for any health outcome. The available comparisons measured growth hormone release against intravenous dosing. In one, a nasal dose about 50 times the intravenous dose gave a similar response. In a study of a closely related analogue, a nasal dose thirty times the intravenous dose released about one fifth as much growth hormone, while an under-the-skin dose ten times the intravenous dose gave a comparable response.
The FDA-approved sermorelin product, Geref, was an injection. A needle-free format is a convenience. It has not been shown to deliver the same amount of drug or the same results.
Does sermorelin nasal spray help with sleep?
One single-night study points to an effect on sleep stages. Twelve young and eleven older healthy men received 300 micrograms of growth hormone-releasing hormone through the nose half an hour before bed, and placebo on another night. After the peptide they had more REM and slow-wave sleep in the second half of the night. Their growth hormone rise in early sleep was smaller, not larger.
That is one night in 23 men, and the abstract does not say the peptide was sermorelin. It did not test weeks of use, and it reports sleep-stage recordings, not how rested people felt. AgelessRx markets its spray for sleep and clearer thinking and describes the nasal route as less established than injection. The customer figures on its page come from a survey of 147 of its own customers, which is not a controlled trial.
What are the side effects of sermorelin nasal spray?
The nasal studies reported local irritation. In the six-month pilot, most of the eight children had sneezing straight after a dose, a runny nose and mild burning in the nose, and two stopped treatment at 6 and 12 weeks. Three had developed antibodies to the peptide by six weeks. In a single-dose study of five children, one reported nasal burning.
Sellers describe similar effects. AgelessRx lists post-nasal drip, burning during use, congestion, flushing of the face or neck, headache and nausea. BMI MD's nasal spray page lists pain, redness or swelling at the place of injection, which is wording for an injection. Ask for the safety information that belongs to the nasal product you are prescribed.
Product quality is a separate question. FDA does not review compounded drugs for safety, effectiveness or quality before they are marketed. A page cannot assess an individual reaction: trouble breathing, swelling of the face or throat, or a severe or fast-worsening reaction needs prompt medical care.
How much does sermorelin nasal spray cost?
BMI MD lists three plans. One month is $129. The three-month plan shows $119 per month with a $357 term total, and the six-month plan shows $109 per month with a $654 term total. The lower monthly figures are equivalents inside a longer term, not one-month prices. Confirm the amount charged at checkout and the renewal date before paying. The page does not state the spray's concentration or bottle size.
AgelessRx advertises $149 for the first month and $199 a month after that, and says the subscription can be paused or canceled. It does not publish a concentration or bottle size either.
LaSara lists a one-month subscription at $199 and a one-month plan at $249. It is the only one of the three that states strength: a 4 mL bottle at 200 micrograms per 0.1 mL, described as a one-month supply at two sprays on weekdays. Its page says to use the spray every morning in one line and in the evening in another, so ask the prescriber which applies.
These are advertised prices checked on October 11, 2026. They are not completed checkout quotes, and the three products are not equivalent prescriptions.
- BMI MD: sermorelin nasal spray plans and term totals
- AgelessRx: sermorelin nasal spray product page
- LaSara Medical Group: sermorelin nasal spray product page
BMI MD's partner offer excludes California and South Carolina. Check your location before continuing, or visit the provider directly. We may earn a commission from a qualifying partner referral. A link is not a recommendation of treatment or proof of a clinical benefit.
What nasal sermorelin doses did the studies use?
The sermorelin studies dosed by body weight and used far more drug than an injection needs. The largest growth hormone response in healthy men came at about 50 micrograms per kg through the nose. The six-month trial in children gave 50 micrograms per kg three times a day.
LaSara is the only seller here that publishes enough to compare. Its bottle holds 8 mg in total and is described as a one-month supply at two sprays on weekdays. By our arithmetic from those figures, that is about 0.4 mg per day of use, or roughly 6 micrograms per kg for a 70 kg adult. The study reported a dose-dependent response, and its abstract does not give the result at an amount that small.
This compares published figures. It is not a dose recommendation, and the study formulations are not the products sold today. The trial that used the larger dose for six months also reported nasal irritation and antibodies. Do not change a prescribed dose because of this page.
Is sermorelin nasal spray FDA-approved?
No. FDA's product database lists two sermorelin applications, both for Geref injections and both discontinued. It lists no nasal sermorelin product. Geref's approvals were withdrawn in 2009 after the manufacturer stopped selling it.
The sprays sold online are compounded. FDA does not verify the safety, effectiveness or quality of compounded drugs before they are marketed, and that holds whichever clinic writes the prescription.
What is the difference between sermorelin nasal spray and sublingual tablets?
Both avoid a needle, and both are compounded products with no FDA approval. The nasal route has the small human absorption studies described above. This review found no published human study of sermorelin absorbed under the tongue.
Neither format has been compared with injections for health outcomes. Compare the exact product, strength, quantity and full bill for each, and do not assume a dose in one format equals a dose in another.
Where can I compare sermorelin injection providers instead?
These links are for injection plans, not nasal products.
The pages below compare public product and contract information. Some are labeled partner links. Any commission we receive does not change evidence claims or table order.
Partner link; we may earn a commission. Editorial order and findings do not change.
Compounded; not FDA-approved. Prescription required only if a licensed provider finds it appropriate.
Which sources support this answer?
Sources were checked October 11, 2026. They define the product, population and evidence limits used above; they do not determine individual suitability.
- PubMed: sermorelin by vein and by nose in 30 healthy men (1993)
- PubMed: six-month intranasal sermorelin pilot in eight children (1993)
- PubMed: single intranasal sermorelin dose in five children (1986)
- PubMed: sermorelin analogue by vein, under the skin and by nose in healthy men (1986)
- PubMed: intranasal GHRH and sleep in 23 healthy men (1999)
- National Library of Medicine: MeSH definition of sermorelin
- FDA: discontinued Geref sermorelin determination
- FDA: understanding the risks of compounded drugs
- AgelessRx: sermorelin nasal spray product page
- BMI MD: sermorelin nasal spray plans and term totals
- LaSara Medical Group: sermorelin nasal spray product page
- FDA: Drugs@FDA record for Geref (sermorelin acetate), listed as discontinued
These are products marketed in the longevity category, not established lifespan-extension treatments. Compounded drugs are not FDA-approved. This publication compares public information; a clinician must assess individual suitability. How we compare.