NAD+ dosage

NAD+ dosage: injection doses, vial strengths and what the studies used

There is no standard NAD+ injection dose. No NAD+ drug is FDA-approved, so no label sets one, and FDA still lists NAD+ as a compounding substance under evaluation. Human data on NAD+ injected under the skin comes from one preprint that gave 100 mg a day for three days to six people. The best-known human study gave 750 mg through an IV drip over six hours. Of the 10 online sellers we checked, only AgelessRx publishes a dose per injection: start at 20 mg and slowly work up to 80 mg, one to three times a week, from a 200 mg per mL vial. The others publish a frequency, a vial or monthly total of 500 to 1,000 mg, or nothing at all. Your prescriber sets your dose. Ask for it in milligrams per injection.

By Iacob Pastina, Independent Researcher & Publisher · Source checks: Regulatory, study and seller pages were read on October 17, 2026.

Three empty glass tumblers of decreasing size in a row on a pale blue table

Sets the only seller-published NAD+ injection dose beside nine sellers' strength disclosures and every human study dose by route, then does the vial arithmetic. It is a bounded source review, not a systematic review or individual medical advice.

FDA-labeled dose

None. No NAD+ drug is FDA-approved

Seller-published dose

1 of 10 sellers: 20 mg rising to 80 mg, 1 to 3 times a week

Most common strength

200 mg per mL, at three sellers

Swipe the evidence table sideways to read every column.

Doses of NAD+ and its oral precursors in human studies, by route
Study	Who	Dose and route	What it found
Grant and colleagues, 2019 Grant et al.: human NAD+ intravenous infusion pilot (2019)	11 men aged 30 to 55: 8 received NAD+, 3 saline	750 mg NAD+ by IV over six hours, once	No adverse events during the infusion; changes in blood and urine markers. It did not measure energy, ageing or other outcomes
Preprint, 2026, not peer-reviewed medRxiv preprint: NAD+ and nicotinamide riboside by injection (2026), not peer-reviewed	In one trial of 45 adults, 6 received NAD+ under the skin, 4 into muscle and 5 by vein	100 mg once a day for three days	Injections were well tolerated, and the main outcome was injection pain. The authors call lower blood pressure across both trials, and a drop in an inflammation marker in the nicotinamide riboside arms, hypothesis-generating. Funded by ChromaDex, which makes a nicotinamide riboside ingredient it also tested
Martens and colleagues, 2018 Martens et al.: nicotinamide riboside in middle-aged and older adults (2018)	30 healthy middle-aged and older adults randomized, 24 completed	Nicotinamide riboside 500 mg twice a day by mouth, six weeks	NAD+ in blood cells about 60% higher than with placebo; well tolerated
Conze and colleagues, 2019 Conze et al.: nicotinamide riboside dose-ranging trial in 140 adults (2019)	140 adults	Nicotinamide riboside 100, 300 or 1,000 mg a day by mouth, eight weeks	Whole-blood NAD+ rose 22%, 51% and 142%; side effects no different from placebo. Funded by the product's maker
Yoshino and colleagues, 2021 Yoshino et al.: NMN in postmenopausal women with prediabetes (2021)	25 postmenopausal women with prediabetes and overweight or obesity; 13 took NMN	NMN 250 mg a day by mouth, 10 weeks	Muscle insulin sensitivity rose; no adverse events reported
Yi and colleagues, 2023 PubMed: Yi et al., NMN dose-ranging trial in 80 adults (2023)	80 healthy middle-aged adults	NMN 300, 600 or 900 mg a day by mouth, 60 days	Safe up to 900 mg; blood NAD was highest at 600 to 900 mg

What does each NAD+ seller publish about dose and strength?

Providers are listed alphabetically. The middle column is the seller's own wording about dose and schedule. Only AgelessRx states a dose per injection.

Seller dose and strength disclosures; source-check dates shown per provider
Provider	Dose and schedule the seller publishes	Published strength or supply	Still missing
AgelessRx NAD+ Source checked October 17, 2026	Start with 0.1 mL (20 mg) and slowly increase to 0.4 mL (80 mg), one to three times a week	200 mg per mL; 2.5 mL (500 mg) vial suggested for new users or up to 50 units a week, 5 mL (1,000 mg) for higher weekly doses. Opened vials are discarded after 28 days	How the dose is adjusted after the first weeks
Embody NAD+ Source checked October 17, 2026	No dose or frequency	500 mg to 1,000 mg injections available; not stated whether per vial or per month	Dose, frequency and concentration
HealthRX NAD+ Source checked October 17, 2026	No dose per injection	1,000 mg of NAD+ per month	Dose per injection, concentration and vial count
Luvo Health NAD+ Source checked October 17, 2026	No dose. Protocols vary by patient; start low and titrate as directed	Not published	Dose, frequency, vial strength and volume
Pallas Health NAD+ Source checked October 17, 2026	No dose in mg. A weekly injection under the skin with clinician-personalized dosing	Not published	Dose per injection, vial strength and volume
PeterMD NAD+ Source checked October 17, 2026	No dose per injection	200 mg per mL; two vials sold as an eight to ten week supply	Vial volume, total milligrams and dose
Sprout Health NAD+ Source checked October 17, 2026	No dose. The prescriber sets dose and schedule; many patients start with a short loading phase, then maintenance doses often one to two times a week	1,000 mg per vial	Milligrams per dose, vial volume and the length of the loading phase
System Labs NAD+ Source checked October 17, 2026	No dose per injection. A quick injection under the skin of the stomach or thigh	1,000 mg, labeled a quarterly supply on the page and a monthly supply in the page data	Dose per injection, concentration and which supply period applies
Wellorithm NAD+ Source checked October 17, 2026	No dose or frequency	500 mg in 2.5 mL (200 mg per mL), in a footnote for its 3-month plan	Dose, frequency and supply per shipment
Willow NAD+ Source checked October 17, 2026	No dose. Your Willow physician prescribes your dose and frequency	Not published	Dose, frequency, vial strength and volume

Eligible partner links are labeled; others go to the seller's official page. We may earn a commission from qualifying partner referrals. Link type does not change the order or the wording in this table.

Is there a standard NAD+ injection dose?

No. FDA's approved-drug data held no NAD+ product when we searched it on October 17, 2026, so no FDA label sets a dose. FDA's compounding list, updated May 14, 2026, places NAD+ among bulk substances still under evaluation for section 503A compounding. While a substance sits in that category, FDA says it does not intend to act against compounders who use it under stated conditions. That is an enforcement policy, not an approval.

A 2026 systematic review found no outcome trials of IV or intramuscular NAD+ itself for anti-ageing or wellness uses. The doses in use come from prescriber judgment and seller protocols, not from trials that compared doses for a health result.

What NAD+ doses have human studies used?

Only two studies gave NAD+ itself. The 2019 IV pilot gave 750 mg over six hours to eight men, once. A 2026 preprint, not yet peer-reviewed and funded by ChromaDex, which makes a nicotinamide riboside ingredient the study also tested, gave 100 mg a day for three days, under the skin to six people, into muscle to four and by vein to five. It mainly measured injection discomfort.

The larger and longer trials tested oral precursors, nicotinamide riboside and NMN, at 100 to 1,000 mg a day for six to ten weeks. The body converts those molecules into NAD+, but they are different products taken by mouth, so their doses do not carry over to an injection.

Do online NAD+ sellers publish a dose?

Only one of the 10 does. AgelessRx is the only seller that publishes a dose per injection. It tells new users to start with 0.1 mL, which is 20 mg, and slowly work up to 0.4 mL, or 80 mg, one to three times a week, from a 200 mg per mL vial sold in 500 mg and 1,000 mg sizes. Pallas describes a weekly injection with clinician-personalized dosing, and Willow says its physician sets the dose and frequency.

Sprout Health says many patients start with a short loading phase, then take maintenance doses often one to two times a week, but gives no milligrams per dose. The rest publish a strength or a total, or nothing. AgelessRx and PeterMD state 200 mg per mL, and Wellorithm's 500 mg in 2.5 mL works out the same. HealthRX, Sprout Health and System Labs advertise 1,000 mg without saying how much goes into each injection. Embody lists 500 mg to 1,000 mg injections without saying whether that is per vial or per month.

How long does a 1,000 mg NAD+ vial last?

Divide the vial's milligrams by your weekly total. Across AgelessRx's published range, the weekly total runs from 20 mg, one 20 mg injection, to 240 mg, three 80 mg injections. At those totals a 1,000 mg vial would last from about four weeks to about 50 weeks. That is our arithmetic from its page, not a schedule. AgelessRx also says an opened vial must be discarded after 28 days, so at low doses much of a 1,000 mg vial goes unused. Follow the discard date on your pharmacy label.

When a seller sells 1,000 mg as one month's supply, as HealthRX does, using it all in a month means about 230 mg a week, close to the top of AgelessRx's range. PeterMD sells two 200 mg per mL vials as an eight to ten week supply without stating the vial volume.

How much NAD+ is in 0.1 mL?

At 200 mg per mL, the strength three sellers state or imply, 0.1 mL holds 20 mg and 0.5 mL holds 100 mg. AgelessRx's instructions match that: 0.1 mL for 20 mg and 0.4 mL for 80 mg. A vial at a different strength changes the arithmetic, so read the concentration on your pharmacy label.

AgelessRx suggests its 2.5 mL vial for new users or anyone taking up to 50 units a week, and the 5 mL vial for higher weekly doses. Its dose instructions use mL while that vial advice uses units, so check which measure your prescription uses.

Are IV, injection and oral NAD+ doses comparable?

No. The 750 mg IV dose ran into a vein over six hours in a supervised study. Injections under the skin are tens of milligrams at a time, and we found no published human data on how much of an injected dose reaches the blood. Embody's page claims about 100% bioavailability for its injections without citing a source.

Oral nicotinamide riboside and NMN are precursors taken in hundreds of milligrams a day.

Compare NAD+ injections and IV infusions

Does a higher NAD+ dose work better?

For oral precursors, higher doses raised blood NAD+ further. In a 140-person trial, 100, 300 and 1,000 mg of nicotinamide riboside a day raised whole-blood NAD+ by 22%, 51% and 142%, and an NMN trial found the highest blood levels at 600 to 900 mg a day. Those are blood measurements, not health outcomes, and both trials had industry ties.

No study has compared NAD+ injection doses for any result, so there is no evidence that a higher injected dose works better. Our side effects guide covers reported reactions to injectable NAD+.

Read NAD+ injection side effects and risks

What should you ask before starting NAD+ injections?

Ask for four numbers in writing: milligrams per injection, injections per week, the vial's strength in mg per mL, and how many weeks the vial should last. Ask whether you start low and increase, as AgelessRx describes, and who adjusts the dose if you react.

Compounded NAD+ is not FDA-approved, and FDA has reminded compounders to use ingredients suitable for sterile injection after adverse event reports. Ask which pharmacy prepares your vial.

Where can I compare current NAD+ providers?

The pages below compare public product and contract information. Some are labeled partner links. Any commission we receive does not change evidence claims or table order.

Partner link; we may earn a commission. Editorial order and findings do not change.

AgelessRx: NAD+ Embody: NAD+ Luvo Health: NAD+ PeterMD: NAD+ RNK Health: NAD+ SHED: NAD+ Sprout Health: NAD+ System Labs: NAD+ Wellorithm: NAD+ Willow: NAD+

Compounded; not FDA-approved. Prescription required only if a licensed provider finds it appropriate.

Sprout Health’s NAD+ injection referral offer excludes California.

Which sources support this answer?

Sources were checked Regulatory, study and seller pages were read on October 17, 2026.. They define the product, population and evidence limits used above; they do not determine individual suitability.

These are products marketed in the longevity category, not established lifespan-extension treatments. Compounded drugs are not FDA-approved. This publication compares public information; a clinician must assess individual suitability. How we compare.