Sermorelin dosage

Sermorelin dosage: the label dose, the study doses and what online plans ship

There is no FDA-approved adult dose of sermorelin. The only labeled dose belonged to Geref, a brand discontinued in 2008 whose approvals FDA withdrew in 2009: 30 micrograms per kg of body weight, injected under the skin once a day at bedtime, for children with growth hormone deficiency. Adult studies used fixed doses instead. A six-month placebo-controlled trial in 89 adults averaging 68 years started the treated group on 1 mg about an hour before bed, and a six-week study in older men used 2 mg a night. None of the 10 online sellers we checked publishes a dose per injection. Five publish a vial size, from 9 to 15 mg, and five describe injecting at night, from up to five times a week to every night. Your prescription sets your dose. Ask for it in micrograms per injection, along with the vial's strength in mg per mL.

By Iacob Pastina, Independent Researcher & Publisher · Source checks: Label, study and seller pages were read on October 17, 2026.

Three empty glass tumblers of decreasing size in a row on a pale blue table

Puts the historical label dose, every adult trial dose and what 10 sellers publish about strength and schedule in one place, then does the vial arithmetic none of them show. It is a bounded source review, not a systematic review or individual medical advice.

FDA-labeled dose

30 mcg per kg nightly, for children only (Geref, discontinued 2008)

Adult study doses

0.5 mg to 2 mg; most dosed once at night, one 14-day study twice a day

Seller pages

0 of 10 publish a dose per injection; published vials hold 9 to 15 mg

Swipe the evidence table sideways to read every column.

Sermorelin doses in the historical label and in human studies
Source	Who	Dose and timing	What it found
Geref label, summarized in a 1999 review PubMed: Prakash and Goa, review of sermorelin in children with growth hormone deficiency (1999) Federal Register: FDA determination that Geref was not withdrawn for safety or effectiveness (2013)	Children with idiopathic growth hormone deficiency	30 micrograms per kg under the skin once a day at bedtime. A single 1 microgram per kg dose by vein was used as a diagnostic test	Height velocity rose in some prepubertal children over 12 months. The review called the treatment data limited
Vitiello and colleagues, 2006 Vitiello et al.: six-month GHRH trial in 89 older adults (2006), full text	89 healthy adults averaging 68 years, men and women, for six months	1 mg, about 14 micrograms per kg, injected about an hour before bed. A few people whose IGF-I barely rose at two weeks moved to about 2 mg	Better scores than placebo on some cognitive tests
Vittone and colleagues, 1997 PubMed: Vittone et al., six weeks of nightly GHRH in 11 older men (1997)	11 men aged 64 to 76, for six weeks	2 mg injected under the skin every night	More growth hormone at night, but IGF-I did not change. The authors concluded that one nightly dose is less effective than several doses a day
Corpas and colleagues, 1992 PubMed: Corpas et al., twice-daily GHRH at two doses in older men (1992)	10 healthy older men, average age 68, for 14 days each dose	0.5 mg or 1 mg under the skin twice a day	Growth hormone and IGF-I rose significantly only at the 1 mg dose
Khorram and colleagues, 1997 PubMed: Khorram et al., 16-week GHRH analogue trial in 19 adults aged 55 to 71 (1997)	10 women and 9 men aged 55 to 71, for 16 weeks	A modified analogue, not sermorelin: 10 micrograms per kg at 9 pm each night	Lean body mass rose in men. Results for a modified molecule do not transfer to sermorelin

What does each sermorelin seller publish about dose and strength?

Providers are listed alphabetically. The middle column is the seller's own wording about dose and schedule; none states a dose per injection. Strength and supply figures come from the same pages.

Seller dose and strength disclosures; source-check dates shown per provider
Provider	Dose and schedule the seller publishes	Published strength or supply	Still missing
AgelessRx sermorelin Source checked October 17, 2026	No dose. Self-injected up to five times a week on a provider-guided titration schedule	Not published	Dose per injection, vial strength and volume
Eden sermorelin Source checked October 17, 2026	No dose per injection	5 mL vial containing 10 mg (2 mg per mL)	Dose per injection, schedule and how long the vial lasts
Embody sermorelin Source checked October 17, 2026	No dose or frequency. The doctor provides the dosing schedule	Not published	Dose, frequency, vial strength and volume
Everlife sermorelin Source checked October 17, 2026	No dose per injection. Five to seven times a week, at night before bed	Injection: 5 mL vial at 3 mg per mL, 15 mg in total. Tablets: 500 or 1,000 micrograms	Dose per injection. The site menu also names a 3 mg injection
Luvo Health sermorelin Source checked October 17, 2026	No dose. Typically a once-daily injection under the skin, often in the evening	Not published	Dose, vial strength and volume. Another answer on the page mentions a weekly cadence
Pallas Health sermorelin Source checked October 17, 2026	No dose. Dosing personalized to your health history	Not published	Dose, frequency, vial strength and volume
PeterMD sermorelin Source checked October 17, 2026	No dose. Most users inject once a night before bed	Four-week and 12-week supplies; strength and volume not published	Dose per injection and vial strength
RNK Health sermorelin Source checked October 17, 2026	No dose per injection	9 mg vial	Dose, frequency and how long the vial lasts
System Labs sermorelin Source checked October 17, 2026	No dose. Once a day at night, 30 to 60 minutes before bed; most clients take five nights on and two off	9 mg, labeled a quarterly supply on the page and a monthly supply in the page data	Dose per injection and which supply period applies
Wellorithm sermorelin Source checked October 17, 2026	No dose or frequency	5 mL vial containing 10 mg (2 mg per mL), with a home kit	Dose, frequency and how long the vial lasts

Eligible partner links are labeled; others go to the seller's official page. We may earn a commission from qualifying partner referrals. Link type does not change the order or the wording in this table.

What is the FDA-approved dose of sermorelin?

Geref, the only sermorelin brand FDA approved, was labeled for children with idiopathic growth hormone deficiency and growth failure. A 1999 review of the drug gives the recommended treatment dose as 30 micrograms per kg of body weight, injected under the skin once a day at bedtime. A single 1 microgram per kg dose by vein served as a diagnostic test. The treatment vials held 0.5 mg or 1 mg.

No adult use was ever labeled. Serono stopped selling Geref in 2008, FDA withdrew both approvals effective June 18, 2009, and FDA later determined the product was not withdrawn for safety or effectiveness reasons. The sermorelin sold online today is compounded and has no label of its own.

What sermorelin doses did adult studies use?

Adult studies used fixed doses of 0.5 to 2 mg, mostly once at night. The longest, a six-month placebo-controlled trial in 89 healthy adults averaging 68 years, started the treated group on 1 mg about an hour before bed, which worked out to about 14 micrograms per kg. A few participants whose IGF-I barely rose after two weeks moved to about 2 mg. A six-week study in 11 men aged 64 to 76 used 2 mg every night. A 14-day study in older men compared 0.5 mg and 1 mg twice a day and found significant effects only at the higher dose.

These were small research studies built to test a hormone response or a specific outcome. The six-week study's authors concluded that a single nightly dose was less effective than several doses a day. In the six-month trial, dose increases were decided by an IGF-I blood test at two weeks, not by how people felt. None of these studies tested the compounded products sold online.

Do online sermorelin sellers publish a dose?

No. None of the 10 sellers in our table publishes a dose per injection. Five state a vial size: 9 mg at RNK Health and System Labs, 10 mg in 5 mL at Eden and Wellorithm, and 15 mg in 5 mL at Everlife. Schedules range from AgelessRx's “up to 5x per week” to PeterMD's note that most users inject once a night before bed. System Labs says once a day at night, 30 to 60 minutes before bed, with most clients taking five nights on and two off.

Two sellers' pages disagree with themselves. System Labs calls its 9 mg supply quarterly on the page and monthly in the page data. Everlife's menu names a 3 mg injection while its product listing describes a 15 mg vial.

Where does the 200 to 300 mcg sermorelin dose come from?

Many dosing guides quote 200 to 300 micrograms a night. We did not find an FDA label or a human trial that used that dose. Adult trials such as Vitiello 2006 and Vittone 1997 used 1 to 2 mg, and the label dose was set per kg of body weight for children.

The range does appear in RxList's sermorelin acetate monograph, which gives 0.2 to 0.3 mg once daily at bedtime in one section and 0.2 to 0.3 mcg in another. Those two figures differ by a factor of 1,000, and the page cites no study for either. That does not make a prescribed dose in this range wrong for you. It means we could not trace the number to published human evidence.

How long does a sermorelin vial last?

Divide the milligrams in the vial by the milligrams in each dose. At the 1 mg nightly starting dose of the six-month trial, a 9 mg vial lasts nine nights and a 15 mg vial lasts 15. At 2 mg a night, the same vials last four and seven full nights.

Sellers' own framing implies much smaller doses. If a 9 mg vial is a monthly supply taken five nights a week, about 22 nights, each dose is roughly 0.4 mg. If System Labs' 9 mg supply is quarterly, the same arithmetic gives roughly 0.14 mg a night. Both are below the doses the adult trials used. Those trials did not set a minimum effective dose, and they used Geref rather than compounded sermorelin, so do not change your dose based on this comparison. These figures are our arithmetic from published vial sizes. A mixed vial also carries a discard date; the one on your pharmacy label applies, whatever the arithmetic says.

How much sermorelin is in 0.1 mL?

That depends on the vial's concentration, and concentrations differ between sellers. Eden's and Wellorithm's vials hold 10 mg in 5 mL, which is 2 mg per mL, so 0.1 mL contains 200 micrograms. Everlife's vial is 3 mg per mL, so 0.1 mL contains 300 micrograms. The same volume drawn from those two vials differs by 50%.

Use the concentration and volume on your pharmacy label and the instructions from your prescriber. If you switch pharmacy or seller, confirm the new concentration before your next injection.

When should you take sermorelin?

At night, in nearly every source we checked. The children's label dose was given at bedtime, the six-month adult trial injected about an hour before bed, and the 1997 analogue trial dosed at 9 pm. Sellers say the same: System Labs says 30 to 60 minutes before bed, and Everlife says five to seven times a week at night before bed.

Frequency is where sources differ. The label and the once-nightly trials dosed every night, one 14-day study dosed twice a day, and several sellers describe five nights a week. No study here compared those schedules.

Is the sermorelin dose different for women?

The studies did not set a separate dose for women. The six-month trial included women and started everyone on the same 1 mg dose. The 16-week analogue study included 10 women and dosed everyone by weight, at 10 micrograms per kg.

Women in the six-month trial were grouped by whether they were taking estrogen, which matters when reading its results. Our guide for women covers what each study measured and found.

See which sermorelin studies included women

Are sermorelin tablets and nasal sprays dosed like injections?

No. Everlife lists sublingual tablets at 500 or 1,000 micrograms, but this review found no published human study of sermorelin absorbed under the tongue. There is no evidence on how a tablet dose compares with an injection.

For the nose, the one human absorption study found that 3% to 5% of the dose was absorbed and that about 50 micrograms per kg was needed to match the response to 1 microgram per kg by vein. Do not assume a dose in one form equals the same number in another. Compounded tablets and sprays, like injections, are not FDA-approved.

Compare sermorelin tablets and injections

Where can I compare current sermorelin providers?

The pages below compare public product and contract information. Some are labeled partner links. Any commission we receive does not change evidence claims or table order.

Partner link; we may earn a commission. Editorial order and findings do not change.

AgelessRx: Sermorelin Embody: Sermorelin Luvo Health: Sermorelin PeterMD: Sermorelin PeterMD: Sermorelin RNK Health: Sermorelin System Labs: Sermorelin Wellorithm: Sermorelin

Compounded; not FDA-approved. Prescription required only if a licensed provider finds it appropriate.

Which sources support this answer?

Sources were checked Label, study and seller pages were read on October 17, 2026.. They define the product, population and evidence limits used above; they do not determine individual suitability.

These are products marketed in the longevity category, not established lifespan-extension treatments. Compounded drugs are not FDA-approved. This publication compares public information; a clinician must assess individual suitability. How we compare.